ANXA1

               (Annexin A1)

  • Alias                                 (According to NCBI)

 
  • ANX1
  • LPC1
  • annexin A1
  • annexin I (lipocortin I)
  • Annexin A1 (Annexin I) (Lipocortin I) (Calpactin II) (Chromobindin 9) (P35) (Phospholipase A2 inhibitory protein).

  • Annexin I belongs to a family of Ca(2+)-dependent phospholipid binding proteins which have a molecular weight of approximately 35,000 to 40,000 and are preferentially located on the cytosolic face of the plasma membrane. Annexin I protein has an apparent relative molecular mass of 40 kDa, with phospholipase A2 inhibitory activity. Since phospholipase A2 is required for the biosynthesis of the potent mediators of inflammation, prostaglandins and leukotrienes, annexin I may have potential anti-inflammatory activity.
  • Location: 9q12-q21
  • Orientation: Plus strand
  • Size: 18,526 bases
  • 13 Exons
  • DNA Sequence: NT_023935

                         

 

  • CGH (9q12-q21): Losses (%) -6.1   Gain (%)  6.7
  • Mutations and SNPs (According to HGMD and SNP)

 
  • m-RNA                       (According to NCBI and CGAP)

 
  • Size: 345 amino acids; 38583 Da
  • Protein domains:

                                                      
  • Pathways and interactions (According to BioCarta, DIP)
  • Clinical                            (According to OMIM, PubMed)