ANXA2

             (Annexin A2)

  • Alias                                 (According to NCBI)

 
  • ANX2
  • ANX2L4
  • CAL1H 
  • LIP2 
  • LPC2
  • LPC2D 
  • Annexin II (lipocortin I) 
  • annexin A2 
  • annexin II (lipocortin II) 
  • annexin II (lipocortin II; calpactin I, heavy polypeptide)
  • arylsulfatase B
  • calpactin I, heavy polypeptide (p36) 
  • Annexin A2 (Annexin II) (Lipocortin II) (Calpactin I heavy chain) (Chromobindin 8) (P36) (Protein I) (Placental anticoagulant protein IV) (PAP-IV).

  • This gene encodes a member of the annexin family. Members of this calcium-dependent phospholipid-binding protein family play a role in the regulation of cellular growth and in signal transduction pathways. This protein functions as an autocrine factor which heightens osteoclast formation and bone resorption. This gene has three pseudogenes located on chromosomes 4, 9 and 10, respectively.
  • Location: 15q21-q22
  • Orientation: Minus strand
  • Size: 50,643 bases
  • 1 Exon
  • DNA Sequence: NT_010194

                        

  • CGH (15q21-q22):  Losses (%) -2.2   Gain (%)  7.8 
  • Mutations and SNPs (According to HGMD and SNP)

 
  • m-RNA                       (According to NCBI and CGAP)

 
  • Size: 338 amino acids; 38472 Da
  • Catalytic activity:
  • Sub cellular location: In the lamina beneath the plasma membrane
  • Protein domains:

              

                                            

  • Protein sequence: P07355
  • Homologous genes: ANXA2
  • 2D PAGE:
  • 3D Structure:
  • PTM: ANXA2
  • Pathways and interactions (According to BioCarta, DIP)
  • Clinical                            (According to OMIM, PubMed)