ANXA5

                            (Annexin A5)

  • Alias                                 (According to NCBI)

 
  • ANX5 
  • ENX2
  • PP4
  • anchorin CII
  • annexin A5
  • annexin V (endonexin II)
  • lipocortin V
  • placental anticoagulant protein I
  • Annexin A5 (Annexin V) (Lipocortin V) (Endonexin II) (Calphobindin I) (CBP-I) (Placental anticoagulant protein I) (PAP-I) (PP4) (Thromboplastin inhibitor) (Vascular anticoagulant-alpha) (VAC-alpha) (Anchorin CII).

  • The protein encoded by this gene belongs to the annexin family of calcium-dependent phospholipid binding proteins some of which have been implicated in membrane-related events along exocytotic and endocytotic pathways. Annexin 5 is a phospholipase A2 and protein kinase C inhibitory protein with calcium channel activity and a potential role in cellular signal transduction, inflammation, growth and differentiation. Annexin 5 has also been described as placental anticoagulant protein I, vascular anticoagulant-alpha, endonexin II, lipocortin V, placental protein 4 and anchorin CII.
  • Location:4q28-q32
  • Orientation: Minus strand
  • Size: 29,028 bases
  • 13 Exons
  • DNA Sequence: NT_016354

                   

 

  • CGH (4q28-q32) : Losses (%) -20.1   Gain (%)  0.6
  • Mutations and SNPs (According to HGMD and SNP)

 
  • m-RNA                       (According to NCBI and CGAP)

 
  • Size: 319 amino acids; 35805 Da
  • Catalytic activity:
  • Sub cellular location: In the lamina beneath the plasma membrane
  • Protein domains:

                

  • Pathways and interactions (According to BioCarta, DIP)
  • Clinical                            (According to OMIM, PubMed)