ATP5B

(ATP Synthase Beta Chain)

 

  • Alias                                 (According to NCBI)

 
  • ATPMB 
  • ATPSB 
  • MGC5231 
  • ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide 
  • mitochondrial ATP synthetase, beta subunit 
  • ATP synthase beta chain, mitochondrial precursor (EC 3.6.3.14).
  • This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. The catalytic portion of mitochondrial ATP synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and a single representative of the other 3. The proton channel consists of three main subunits (a, b, c). This gene encodes the beta subunit of the catalytic core.
  • Location: 12q13.13
  • Orientation: minus strand
  • Size: 7,891 bp
  • 9 exons
  • DNA sequence (Human):  NC_000012

  • CGH (12q13.13):  Losses (%) -1.7   Gain (%)  8.4
  • Mutations and SNPs (According to HGMD and SNP)

 
  • m-RNA                       (According to NCBI and CGAP)

 

  • mRNA sequence (Human): NM_001686

  • Size: 1857 bp

  • cDNA libraries: ATP5B
  • Size: 529 amino acids; 56560 Da
  • Catalytic activity: ATP + H(2)O + H(+)(In) = ADP + phosphate + H(+)(Out).
  • Subcellular location: Mitochondrial.
  • Protein domains

  • Pathways and interactions (According to BioCarta, DIP)

 

 

 

 

 
  • Clinical                            (According to OMIM, PubMed)