BIRC5

                                                                                                            (Baculoviral IAP repeat-containing protein 5) 

  • Alias                                 (According to NCBI)

 
  • API4
  • EPR-1 
  • IAP4
  • SURVIVIN 
  • SVV
  • apoptosis inhibitor 4
  • apoptosis inhibitor 4 (survivin)
  • baculoviral IAP repeat-containing 5
  • baculoviral IAP repeat-containing 5 (survivin)
  • Baculoviral IAP repeat-containing protein 5 (Apoptosis inhibitor survivin) (Apoptosis inhibitor 4).

  • The protein encoded by this gene is an apoptosis inhibitor that is expressed during the G2/M phase of the cell cycle. BIRC5 associates with the microtubules of the mitotic spindle and any disruption results in the loss of apoptosis activity.
  • Location: 17q25
  • Orientation: Plus strand
  • Size: 10,428 bases
  • 5 Exons
  • DNA Sequence: NT_010641

  • CGH (17q25): Losses (%) -1.7  Gain (%)  11.2  

 
  • Mutations and SNPs (According to HGMD and SNP)

 
  • m-RNA                       (According to NCBI and CGAP)

 
  • Size: 142 amino acids; 16389 Da
  • Sub cellular location: Cytoplasmic
  • Protein domains:
     

              

  • Pathways and interactions (According to BioCarta, DIP)
  • Pathways:
  • Interactions:
  • Clinical                            (According to OMIM, PubMed)