Myc

                                                                      (v-myc myelocytomatosis viral oncogene homolog (avian)) 

Alias                                 (According to NCBI)	C-MYC c-Myc v-myc avian myelocytomatosis viral oncogene homolog  v-myc myelocytomatosis viral oncogene homolog (avian) Myc proto-oncogene protein (c-myc)
Description    (According to SwissProt)	Participates in the regulation of gene transcription. Binds DNA both in a non-specific manner and also        specifically to recognize the core sequence CAC [GA] TG. Seems to activate the transcription of growth-related     genes.
Chromosomal location (According to NCBI, CGH: progenetix)	Location: 8q24.12-q24.13 Orientation: Plus strand Size: 5,167 bp 3 Exons DNA sequence: NT_008046 CGH (8q24.12- 24.13)):  Losses (%) -0.0  Gain (%)  40.2
Mutations and SNPs (According to HGMD and SNP)	HGMD: MYC SNPs: MYC
m-RNA                       (According to NCBI and CGAP)	m-RNA Sequence: NT_008046 Size: 2189 bp c-DNA Libraries: c-Myc
Protein                        (According to SwissProt, Swiss2D, PDB)	Size: 439 amino acids; 48804 Da Sub cellular location: Nuclear Protein domains:          Protein sequence: P01106 Homologous genes: c-Myc 2D PAGE: P01106 3D Structure: 1A93 PTM:
Pathways and interactions (According to BioCarta, DIP)	PATHWAYS:  Cadmium induces DNA synthesis and proliferation in macrophages. Erk1/Erk2 Mapk signaling pathway. IL-2 Receptor Beta Chain in T cell Activation. IL-7 Signal Transduction. Inhibition of Cellular Proliferation by Gleevec. MAPKinase Signaling Pathway. Mechanism of Gene Regulation by Peroxisome Proliferators via PPARa(alpha). mTOR Signaling Pathway. Neuropeptides VIP and PACAP inhibit the apoptosis of activated T cells. Overview of telomerase protein component gene hTert Transcriptional Regulation. p38 MAPK Signaling Pathway. Regulation of eIF4e and p70 S6 Kinase. Role of EGF Receptor Transactivation by GPCRs in Cardiac Hypertrophy. Skeletal muscle hypertrophy is regulated via AKT/mTOR pathway. Stat3 Signaling Pathway. Telomeres, Telomerase, Cellular Aging, and Immortality. Tumor Suppressor Arf Inhibits Ribosomal Biogenesis. WNT Signaling Pathway. Interactions: P01106
Tissue (According to GeneNote, PubMed, HPA)	Tissue expression: PubMed Reference Human Protein Atlas (HPA): CAB000084
Clinical                            (According to OMIM, PubMed)	OMIM:190080 PubMed:    Early detection      Diagnosis         Prognosis        Therapy