CAV1

                                                                                                                                              (Caveolin-1)

  • Alias                                 (According to NCBI)

 
  • CAV
  • VIP21
  • caveolae protein, 22-kD 
  • caveolin 1 caveolae protein, 22kD 
  • caveolin 1, alpha isoform
  • caveolin 1, beta isoform
  • caveolin 1, caveolae protein, 22kD 
  • caveolin 1, caveolae protein, 22kDa
  • Caveolin-1.

  • The scaffolding protein encoded by this gene is the main component of the caveolae plasma membranes found in most cell types. The protein links integrin subunits to the tyrosine kinase FYN, an initiating step in coupling integrins to the Ras-ERK pathway and promoting cell cycle progression. The gene is a tumor suppressor gene candidate and a negative regulator of the Ras-p42/44 MAP kinase cascade. CAV1 and CAV2 are located next to each other on chromosome 7 and express co localizing proteins that form a stable hetero-oligomeric complex. By using alternative initiation codons in the same reading frame, two isoforms (alpha and beta) are encoded by a single transcript from this gene.
  • Location:7q31.1
  • Orientation: Plus strand
  • Size:36,391 bases
  • 3 Exons
  • DNA Sequence: NT_007933

  • CGH (7q31.1):  Losses (%) -3.9   Gain (%)  7.8  
  • Mutations and SNPs (According to HGMD and SNP)

 
  • m-RNA                       (According to NCBI and CGAP)

 
  • Size:178 amino acids; 20471 Da
  • Sub cellular location: Membrane protein of caveolae. Potential hairpin-like structure in the
    membrane.
  • Protein domains:

                     

 

  • Protein sequence: Q03135
  • Homologous genes: CAV-1
  • 2D PAGE:
  • 3D Structure:
  • PTM: CAV1
  • Pathways and interactions (According to BioCarta, DIP)
  • Clinical                            (According to OMIM, PubMed)