Cyclin D1

(G1/S-specific Cyclin D1)

Alias (According to NCBI)	BCL1 D11S287E HGNC: 988 PRAD1 U21B31 B-cell CLL/lymphoma 1 G1/S-specific Cyclin D1 Cyclin D1 (PRAD1: parathyroid adenomatosis 1) G1/S-specific Cyclin D1 (PRAD1 oncogene) (BCL-1 oncogene).
Description (According to SwissProt)	Essential for the control of the cell cycle at the G1/S (start) transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and over expression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumor genesis
Chromosomal location (According to NCBI, CGH: progenetix)	Location: 11q13.3 Orientation: plus strand Size: 13,368 bp 5 Exons DNA sequence: NT_078088 CGH (11q13.3): Losses (%) -3.4 Gain (%) 34.1
Mutations and SNPs (According to HGMD and SNP)	HGMD: Cyclin D1 SNP: Cyclin d1
m-RNA (According to NCBI and CGAP)	m-RNA sequence: 2 Transcript variants: NP_001749 , NP_444284.1 c-DNA libraries: Cyclin D1
Protein (According to SwissProt, Swiss2D, PDB, dbPTM)	Size: 295 amino acids; 33729 Da Protein domains: Protein sequence: P24385 Homologous genes: Cyclin D1 2D PAGE: 3D Structure: PTM: Cyclin D1
Pathways and interactions (According to BioCarta, DIP)	Pathways: CARM1 and Regulation of the Estrogen Receptor Cell Cycle: G1/S Check Point Cyclins and Cell Cycle Regulation Inactivation of Gsk3 by AKT causes accumulation of b-catenin in Alveolar Macrophages Influence of Ras and Rho proteins on G1 to S Transition p53 Signaling Pathway WNT Signaling Pathway Interactions:P24385.
Tissue (According to GeneNote, PubMed, HPA)	Tissue expression: PubMed Reference Human Protein Atlas (HPA) : CAB000024
Clinical (According to OMIM, PubMed)	OMIM:168461 PubMed: Early detection Diagnosis Prognosis Therapy