• Alias

• CDK1 
• cell cycle controller CDC2
• cell division control protein 2 homolog
• cell division cycle 2, G1 to S and G2 to M
• cyclin-dependent kinase 1
• p34 protein kinase 
• Cell division control protein 2 homolog (EC 2.7.1.37) (p34 protein kinase) (Cyclin-dependent
  kinase 1) (CDK1)

• Description

• The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is a catalytic subunit of the highly conserved protein kinase complex known as M-phase promoting factor (MPF), which is essential for G1/S and G2/M phase transitions of eukaryotic cell cycle. Mitotic cyclins stably associate with this protein and function as regulatory subunits. The kinase activity of this protein is controlled by cyclin accumulation and destruction through the cell cycle. The phosphorylation and dephosphorylation of this protein also play important regulatory roles in cell cycle control.

• Chromosomal location

  (According to LocusLink,     

   progenetix)

• Location: 10q21.1
• Orientation: Plus strand
• Size: 15,688 bases
• 8 Exons
• DNA Sequence: NT_008583
• m-RNA Sequence: 2 Transcript variants: NM_001786, NM_033379
• c-DNA Libraries:CDC2

      CGH (10q22.1):  Losses (%) -11.7   Gain (%)  2.2  

• Amplifications

• Prognostic significance of p34cdc2 expression in tongue squamous cell carcinoma.
• The localization of p34cdc2 in the cells of normal, hyperplastic, and malignant epithelial and lymphoid tissues of the oral cavity.

• Mutations and SNPs

• m-RNA

• Protein(According to SwissProt)

• Size: 297 amino acids; 34095 Da
• Sub cellular location: Nuclear
• Catalytic activity: ATP + a protein = ADP + a phosphoprotein
• Protein domains:

• Protein sequence: P06493
• Homologous genes: CDC2

• Pathways and interactions (According to BioCarta, DIP)

• Pathways: Activation of Src by Protein-tyrosine phosphatase alpha
• AKAP95 role in mitosis and chromosome dynamics
• cdc25 and chk1 Regulatory Pathway in response to DNA damage
• Cell Cycle: G1/S Check Point
• Cell Cycle: G2/M Checkpoint
• Cyclins and Cell Cycle Regulation
• HIV-I Nef: negative effector of Fas and TNF
• How Progesterone Initiates the Oocyte Maturation
• Protein Kinase A at the Centrosome
• RB Tumor Suppressor/Checkpoint Signaling in response to DNA damage
• Regulation of cell cycle progression by Plk3
• Regulation of p27 Phosphorylation during Cell Cycle Progression
• Sonic Hedgehog (SHH) Receptor Ptc1 Regulates cell cycle
• Interactions: P06493

• Tissue

  (According to GeneNote

   expression array results)

• Clinical

• OMIM:116940
• Colon cancer: Enhanced sensitivity to irinotecan by Cdk1 inhibition in the p53-deficient HT29 human colon cancer cell line.
• Hepatocellular carcinoma: Cyclins and cyclin-dependent kinases: comparative study of hepatocellular carcinoma versus cirrhosis.
• Breast cancer: Cyclin b1 promoter activity and functional cdk1 complex formation in G1 phase of human breast cancer cells.