CDH17

Cadherin 17

  • Alias                                 (According to NCBI)

 
  • CDH16
  • HPT-1
  • HPT1
  • cadherin
  • cadherin-16
  • HPT-1 cadherin
  • Human intestinal peptide-associated transporter HPT-1 mRNA, complete cds
  • LI cadherin 
  • cadherin 17, LI cadherin (liver-intestine)
  • human peptide transporter 1
  • liver-intestine cadherin
  • Cadherin-17 precursor (Liver-intestine-cadherin) (LI-cadherin) (Intestinal peptide-associated
    transporter HPT-1).

  • This gene is a member of the cadherin superfamily, genes encoding calcium-dependent, membrane-associated glycoproteins. The encoded protein is cadherin-like, consisting of an extracellular region, containing 7 cadherin domains, and a transmembrane region but lacking the conserved cytoplasmic domain. The protein is a component of the gastrointestinal tract and pancreatic ducts, acting as an intestinal proton-dependent peptide transporter in the first step in oral absorption of many medically important peptide-based drugs. The protein may also play a role in the morphological organization of liver and intestine.
  • Location: 8q22.1
  • Orientation: minus strand
  • Size: 81419 bp
  • 18 exons
  • DNA sequence (Human):  NC_000008

  • CGH (8q22.1):  Losses (%) -0.0  Gain (%) 31.8    

  • Mutations and SNPs (According to HGMD and SNP)
  • HGMD (Human Gene Mutation Database):
  • SNPs: CDH17

 
  • m-RNA                       (According to NCBI and CGAP)

 
  • Size: 832 amino acids; 92147 Da
  • Catalytic activity:?

  • Subcellular location: Type I membrane protein

  • Protein domains

  • Pathways and interactions (According to BioCarta, DIP)

  • Pathway:

  • Protein interactions:

 
 

 

 
  • Clinical                            (According to OMIM, PubMed)