CDK4

                                                                                                  (cyclin-dependent kinase 4)

  • Alias                                 (According to NCBI)

 
  • CMM3
  • MGC14458
  • PSK-J3
  • cell division kinase 4 
  • cyclin-dependent kinase 4
  • melanoma cutaneous malignant, 3
  • Cell division protein kinase 4 (EC 2.7.1.37) (Cyclin-dependent kinase 4) (PSK-J3).

  • The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb). Mutations in this gene as well as in its related proteins including D-type cyclins, p16(INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers.
  • Location: 12q14
  • Orientation: Minus strand
  • Size: 4,159 bases
  • 8 Exons
  • DNA Sequence: NT_029419

  • CGH (12q14):  Losses (%) -2.2   Gain (%)  9.5  

  • Mutations and SNPs (According to HGMD and SNP)
  • m-RNA                       (According to NCBI and CGAP)

 
  • Size:303 amino acids; 33730 Da
  • Catalytic activity: ATP + a protein = ADP + a phosphoprotein
  • Protein domains:

              

  • Protein sequence: P11802
  • Homologous genes: CDK4
  • 2D PAGE:
  • 3D Structure:
  • PTM: CDK4
  • Pathways and interactions (According to BioCarta, DIP)
  • Clinical                            (According to OMIM, PubMed)