CES2

Carboxylesterase 2

 

  • Alias                                 (According to NCBI)

 
  • CE-2
  • hCE-2
  • iCE
  • carboxylesterase 2 (intestine, liver)
  • intestinal carboxylesterase; liver carboxylesterase-2
  • Carboxylesterase 2 precursor (EC 3.1.1.1) (CE-2) (hCE-2).

  • Carboxylesterase 2 is a member of a large multigene family. The enzymes encoded by these genes are responsible for the hydrolysis of ester- and amide-bond-containing drugs such as cocaine and heroin. They also hydrolize long-chain fatty acid esters and thioesters. The specific function of this enzyme has not yet been determined; however, it is speculated that carboxylesterases may play a role in lipid metabolism and/or the blood-brain barrier system. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
  • Location: 16q22.1
  • Orientation: plus strand
  • Size: 10653 bp
  • 12 exons
  • DNA sequence (Human):  NC_000016 


  • CGH (16q22.1):  Losses (%) -3.4  Gain (%)  7.8

  • Mutations and SNPs (According to HGMD and SNP)
  • HGMD (Human Gene Mutation Database):
  • SNPs: CES2

 
  • m-RNA                       (According to NCBI and CGAP)

 
  • Size: 559 amino acids; 61806 Da
  • Catalytic activity: A carboxylic ester + H(2)O = an alcohol + a carboxylic anion.

  • Subcellular location: Endoplasmic reticulum lumen

  • Protein domains

  • Pathways and interactions (According to BioCarta, DIP)

  • Pathway:

  • Protein interactions:

 

  • Clinical                            (According to OMIM, PubMed)