Cox1 / ptgs1

                                                       (prostaglandin-endoperoxide synthase 1)

  • Alias                                 (According to NCBI)

 
  • COX1
  • PGHS-1
  • PTGHS
  • prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
  • Prostaglandin G/H synthase 1 precursor (EC 1.14.99.1) (Cyclooxygenase -1) (COX-1) (Prostaglandin-endoperoxide synthase 1) (Prostaglandin H2 synthase 1) (PGH synthase 1) (PGHS-1) (PHS 1).

  •  Prostaglandin-endoperoxide synthase (PTGS), also known as cyclooxygenase, is the key enzyme in prostaglandin biosynthesis, and acts both as a dioxygenase and as a peroxidase. This gene encodes PTGS1, which regulates angiogenesis in endothelial cells, and is inhibited by nonsteroidal anti-inflammatory drugs such as aspirin. PTGS1 is thought to be involved in cell-cell signaling and maintaining tissue homeostasis. May play an important role in regulating or promoting cell proliferation in some normal and neoplastically transformed cells.
  • Location:9q32-q33.3
  • Orientation: Plus strand
  • Size: 24,752 bases
  • 11 Exons
  • DNA Sequence: NT_008470

                            

  • CGH ( 9q32-33.3) :  Losses (%) -3.4    Gain (%) 8.9  
  • Mutations and SNPs (According to HGMD and SNP)
  • m-RNA                       (According to NCBI and CGAP)

 
  •  Size:599 amino acids; 68656 Da
  • Catalytic activity: Arachidonate + AH(2) + 2 O(2) = prostaglandin H2 + A + H(2)O
  • Sub cellular location: Membrane-associated. Microsomal membrane
  • Protein domains:

                           

                                                  

                         

  • Pathways and interactions (According to BioCarta, DIP)
          

                                          

  • Clinical                            (According to OMIM, PubMed)