CTSB

                                                                                                       (Cathepsin B)

  • Alias                                 (According to NCBI)

 
  • APPS 
  • CPSB
  • APP secretase
  • amyloid precursor protein secretase
  • cathepsin B
  • cathepsin B1
  • preprocathepsin B
  • Cathepsin B precursor (EC 3.4.22.1) (Cathepsin B1) (APP secretase) (APPS).

  • The protein encoded by this gene is a lysosomal cysteine proteinase composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. It is also known as amyloid precursor protein secretase and is involved in the proteolytic processing of amyloid precursor protein (APP). Incomplete proteolytic processing of APP has been suggested to be a causative factor in Alzheimer disease, the most common cause of dementia. Overexpression of the encoded protein, which is a member of the peptidase C1 family, has been associated with esophageal adenocarcinoma and other tumors.
  • Location: 8p22
  • Orientation: Minus strand
  • Size:23,808 bases
  • 10 Exons
  • DNA Sequence: NT_077531

                 

  • CGH (8p22):  Losses (%)  -35.8 Gain (%)  3.9 

  • Mutations and SNPs (According to HGMD and SNP)
  • m-RNA                       (According to NCBI and CGAP)

 
  • Size: 339 amino acids; 37807 Da
  • Sub cellular location: Lysosomal
  • Catalytic activity: Hydrolysis of proteins with broad specificity for peptide bonds. Preferentially
    cleaves -Arg-Arg-
  • Protein domains:

              

 
  • Pathways and interactions (According to BioCarta, DIP)
  • Pathways:
  • Interactions:

 
  • Clinical                            (According to OMIM, PubMed)