Alias (According to NCBI)
- AHH
- AHRR
- CP11
- CYP1
- P1-450
- P450-C
- P450DX
- P450 form 6
- aryl hydrocarbon hydroxylase
- cytochrome P1-450, dioxin-inducible
- cytochrome P450, family 1, subfamily A, polypeptide 1
- cytochrome P450, subfamily I (aromatic compound-inducible), polypeptide 1
- flavoprotein-linked monooxygenase
- microsomal monooxygenase
- xenobiotic monooxygenase
- Cytochrome P450 1A1 (EC 1.14.14.1) (CYPIA1) (P450-P1) (P450 form 6) (P450-C).
Description
(According to SwissProt)
This gene, CYP1A1, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates.
- Chromosomal location
(According to NCBI, CGH: progenetix)
- Location: 15q22-q24
- Orientation: Minus strand
- Size: 5,987 bases
- 7 Exons
- DNA Sequence: NT_010194
CGH (15q22-24): Losses (%) -1.7 Gain (%) 8.4
- Size: 512 amino acids; 58165 Da
- Sub cellular location: Membrane-bound. Endoplasmic reticulum.
- Protein domains:
- Pathways: Mechanism of Acetaminophen Activity and Toxicity
- Interactions:
- Tissue expression: PubMed Reference
- Human Protein Atlas (HPA): CAB018654
- OMIM: 108330
- PubMed: Early detection Diagnosis Prognosis Therapy