CYP3A5P2

(Cytochrome P450, family 3, subfamily A, polypeptide 5 pseudogene 2)

 

  • Alias                                 (According to NCBI)

 
  • cytochrome P450, family 3, subfamily A, polypeptide 5 pseudogene 2
  • cytochrome P450, subfamily IIIA, polypeptide 5 pseudogene 2
  • cytochrome P450, subfamily IIIA, pseudogene 2

  • Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
  • Location: 7q21.3-q22.1
  • Orientation: minus strand
  • Size: 4,242 bp
  •  2  exons
  • DNA sequence (Human): NC_000007

  • CGH (7q21.3 - 22.1):  Losses (%) - 2.8  Gain (%) 11.2  

  • Mutations and SNPs (According to HGMD and SNP)
  • m-RNA                       (According to NCBI and CGAP)

 

  • mRNA sequence (Human):

  • Size:

  • cDNA libraries:
  • Size: 502 a.a., 57,109 Da
  • Catalytic activity:RH + reduced flavoprotein + O(2) = ROH + oxidized flavoprotein + H(2)O.

  • Subcellular location: RH + reduced flavoprotein + O(2) = ROH + oxidized flavoprotein + H(2)O.

  • Protein domains

  • Protein sequence (Human): P20815

  • Homologous genes:

  • 2D PAGE:

  • 3D Structure:

  • PTM:

  • Pathways and interactions (According to Kegg, DIP)

  • Pathway:  hsa00361  gamma-Hexachlorocyclohexane degradation
     hsa00591  Linoleic acid metabolism
     hsa00830  Retinol metabolism
     hsa00980  Metabolism of xenobiotics by cytochrome P450
     hsa00982  Drug metabolism - cytochrome P450
     hsa00983  Drug metabolism - other enzymes

  • Protein interactions:

  • Clinical                            (According to OMIM, PubMed)