CYPA

                                                                            (Peptidylprolyl isomerase A (cyclophilin A))

  • Alias                                 (According to NCBI)

 
  • PPIA
  • CYPA
  • CYPH 
  • MGC12404
  • rotamase
  • T cell cyclophilin 
  • cyclophilin A
  • cyclosporin A-binding protein 
  • peptidyl-prolyl cis-trans isomerase A
  • peptidylprolyl isomerase A (cyclophilin A)
  • Peptidyl-prolyl cis-trans isomerase A (EC 5.2.1.8) (PPIase) (Rotamase) (Cyclophilin A)
    (Cyclosporin A-binding protein).

  • The protein encoded by this gene is a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. This protein is a cyclosporin binding-protein. It may play a role in cyclosporin A-mediated immunosuppression. This protein can interact with several HIV proteins including p55 gag, Vpr, and capsid protein. It has been shown to be necessary for the formation of infectious HIV virions. Multiple pseudogenes that map to different chromosomes have been reported.
  • Location: 7p13-p11.2
  • Orientation: Plus strand
  • Size: 4,952 bases
  • 5 Exons
  • DNA Sequence: NT_007819

                      

  • CGH (7p11.2-13):  Losses (%)  -1.1 Gain (%)  10.6 

  • Mutations and SNPs (According to HGMD and SNP)
  • m-RNA                       (According to NCBI and CGAP)

 
  • Size: 164 amino acids; 17881 Da
  • Sub cellular location: Cytoplasmic
  • Catalytic activity: Peptidylproline (omega= 180)= peptidylproline (omega=0)
  • Protein domains:

                           
  • Pathways and interactions (According to BioCarta, DIP)
  • Clinical                            (According to OMIM, PubMed)