DBI

Diazepam Binding Inhibitor

  • Alias                                 (According to NCBI)

 
  • ACBD1
  • ACBP
  • endozepine
  • GABA receptor modulator
  • acyl coenzyme A binding protein
  • acyl-Coenzyme A binding domain containing 1
  • diazepam binding inhibitor (GABA receptor modulator, acyl-Coenzyme A binding protein)
  • Acyl-CoA-binding protein (ACBP) (Diazepam binding inhibitor) (DBI) (Endozepine) (EP).

  • Binds medium- and long-chain acyl-CoA esters with very high affinity and may function as an intracellular carrier of acyl-CoA esters. It is also able to displace diazepam from the benzodiazepine (BZD) recognition site located on the GABA type A receptor. It is therefore possible that this protein also acts as a neuropeptide to modulate the action of the GABA receptor.
  • Location: 2q12-q21
  • Orientation: plus strand
  • Size:  4975 bp
  • 4 exons
  • DNA sequence (Human): NC_000002 


 

  • CGH (2q12-21):  Losses (%) -2.2  Gain (%)  4.5 

  • Mutations and SNPs (According to HGMD and SNP)
  • HGMD:
  • SNPs: DBI
  • m-RNA                       (According to NCBI and CGAP)

 

  • mRNA sequence (Human): NM_020548

  • Size: 730 bp

  • cDNA libraries: DBI
  • Size: 86 amino acids; 9913 Da
  • Catalytic activity:

  • Subcellular location:

  • Protein domains

 

  • Protein sequence (Human): P07108

  • Homologous genes: DBI

  • 2D PAGE: P07108

  • 3D Structure:

  • PTM: DBI
  • Pathways and interactions (According to BioCarta, DIP)

  • Pathway:

  • Protein interactions:

  • Clinical                            (According to OMIM, PubMed)