DCN

                                                                                                                                     (Decorin)

  • Alias                                 (According to NCBI)

 
  • DSPG2
  • PG40
  • PGII
  • PGS2
  • SLRR1B
  • decorin
  • bone proteoglycan II
  • dermatan sulphate proteoglycans II
  • proteoglycan core protein
  • small leucine-rich protein 1B 
  • Decorin precursor (Bone proteoglycan II) (PG-S2) (PG40).

  • The protein encoded by this gene is a small cellular or pericellular matrix proteoglycan that is closely related in structure to biglycan protein. The encoded protein and biglycan are thought to be the result of a gene duplication. This protein is a component of connective tissue, binds to type I collagen fibrils, and plays a role in matrix assembly. It contains one attached glycosaminoglycan chain. This protein is capable of suppressing the growth of various tumor cell lines. There are multiple alternatively spliced transcript variants known for this gene. This gene is a candidate gene for Marfan syndrome.
  • Location: 12q13.2
  • Orientation: Minus strand
  • Size: 37,293 bases
  • 8 Exons
  • DNA Sequence: NT_019546

              

  • CGH (12q13.2):  Losses (%)  -1.7 Gain (%)  8.9 

  • Mutations and SNPs (According to HGMD and SNP)
  • m-RNA                       (According to NCBI and CGAP)

 
  • Size: 359 amino acids; 39746 Da
  • Sub cellular location: Secreted; extracellular matrix
  • Protein domains:

              

                            

  • Protein sequence: P07585
  • Homologous genes: DCN
  • 2D PAGE:
  • 3D Structure:
  • PTM: DCN
  • Pathways and interactions (According to BioCarta, DIP)
  • Clinical                            (According to OMIM, PubMed)