DNASE1L3

(Deoxyribonuclease I-like 3)

 

  • Alias                                 (According to NCBI)

 
  • DNAS1L3
  • LSD
  • deoxyribonuclease I-like 3
  • Deoxyribonuclease gamma precursor (EC 3.1.21.-) (DNase gamma) (Deoxyribonuclease I-like 3) (DNase
    I homolog protein DHP2) (Liver and spleen DNase) (LS-DNase) (LSD).
  • This gene encodes a member of the DNase family. The protein hydrolyzes DNA, is not inhibited by actin, and mediates the breakdown of DNA during apoptosis. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized
  • Location: 3p21.1-3p14.3
  • Orientation: minus strand
  • Size:18333 bp
  •  8 exons
  • DNA sequence (Human): NC_000003  

  • CGH (3p14.3 - 21.1):  Losses (%) -30.7       Gain (%) 0.6       
  • Mutations and SNPs (According to HGMD and SNP)
  • m-RNA                       (According to NCBI and CGAP)

 

 
  • Size:305 amino acids; 35504 Da
  • Catalytic activity:

  • Subcellular location: Nuclear; may first pass through the ER membrane before being imported in the nucleus.

  • Protein domains :

 

                               
  • Pathways and interactions (According to BioCarta, DIP)

  • Pathway:

  • Protein interactions:
  • Clinical                            (According to OMIM, PubMed)