DOC1 / CDK2AP1

                                                                                                (CDK2-associated protein 1)                        

  • Alias                                 (According to NCBI)

 
  • CDK2AP1
  • GIP90
  • GPBP-interacting protein 90
  • downregulated in ovarian cancer 1
  • DOC1

  • The protein encoded by this gene is a specific CDK2-associated protein, which is thought to negatively regulate CDK2 activity by sequestering monomeric CDK2, and targeting CDK2 for proteolysis. This protein was found to also interact with DNA polymerase alpha/primase and mediate the phosphorylation of the large p180 subunit, which suggested the regulatory role in DNA replication during S phase of the cell cycle. A similar gene in hamster was isolated from, and functions as a growth suppressor of normal keratinocytes.
  • Location: 12q24.31
  • Orientation: Minus strand
  • Size: 281,368 bases
  • 6 Exons
  • DNA Sequence: NT_009755

               

  • CGH (12q24.31):  Losses (%)  -2.2 Gain (%)  4.5 

  • Mutations and SNPs (According to HGMD and SNP)
  • m-RNA                       (According to NCBI and CGAP)

 
  • Size: 752 amino acids; 87141 Da
  • Protein domains:

                             

  • Protein sequence: Q13597
  • Homologous genes: DOC1
  • 2D PAGE:
  • 3D Structure:
  • PTM: DOC1
  • Pathways and interactions (According to BioCarta, DIP)
  • Pathways:
  • Interactions:
  • Clinical                            (According to OMIM, PubMed)