EGFR

(Epidermal Growth Factor Receptor)

 

  • Alias                                 (According to NCBI)

 
  • EGFR - epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)
  • ERBB
  • ERBB1
  • S7
    •
  • Receptor for EGF, but also for other members of the EGF family, as TGF-alpha, amphiregulin, betacellulin, heparin-binding EGF-like growth factor, GP30 and vaccinia virus growth factor. Is involved in the control of cell growth and differentiation.
  • Location: 7p12
  • Orientation: plus strand
  • Size: 197496 bp
  • 28 exons
  • DNA sequence (Human): AF288738

  • CGH (7p12):  Losses (%) -1.1    Gain (%)  11.7  

  • Mutations and SNPs (According to HGMD and SNP)
  • m-RNA                       (According to NCBI and CGAP)

 

  • mRNA sequence (Human): NM_005228

  • Size: 5616 bp

  • cDNA libraries: EGFR
  • Size: 1210 amino acids; 134277 Da
  • Catalytic activity: ATP + a protein tyrosine = ADP + protein tyrosine phosphate.

  • Subcellular location: Type I membrane protein. Isoform 2 is secreted.

  • Protein domains

                          
  • Pathways and interactions (According to BioCarta, DIP)

  • Pathways:

  1. Actions of Nitric Oxide in the Heart

  2. Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling

  3. CBL mediated ligand-induced downregulation of EGF receptors

  4. EGF Signaling Pathway

  5. Erk1/Erk2 Mapk Signaling pathway

  6. Keratinocyte Differentiation

  7. Map Kinase Inactivation of SMRT Corepressor

  8. mCalpain and friends in Cell motility

  9. Neuroregulin receptor degredation protein-1 Controls ErbB3 receptor recycling

  10. Role of EGF Receptor Transactivation by GPCRs in Cardiac Hypertrophy

  11. Sprouty regulation of tyrosine kinase signals

  12. Telomeres, Telomerase, Cellular Aging, and Immortality

  13. The role of FYVE-finger proteins in vesicle transport

  14. VEGF, Hypoxia, and Angiogenesis

  • Protein interactions: 5764N
  • Clinical                            (According to OMIM, PubMed)