• Alias                                 (According to NCBI)

• NNE non-neural enolase
• PPH  phosphopyruvate hydratase
• MPB1 MYC promoter-binding protein 1
• MBPB1
• ENO1L1
• 2-phospho-D-glycerate hydro-lyase
• C-myc promotor binding protein
• alpha enolase like 1
• tau-crystallin
• plasminogen binding protein

• Description   

  (According to SwissProt)

• Multifunctional enzyme that, as well as its role in glycolysis, plays a part in various processes such as growth control, hypoxia tolerance and allergic responses. May also function in the intravascular and pericellular fibrinolytic system due to its ability to serve as a receptor and activator of plasminogen on the cell surface of several cell-types such as leukocytes and neurons.
• Isoform, MBP1 binds to the c-myc promoter and acts as a transcriptional repressor. May be a tumor suppressor.

• Chromosomal location

  (According to NCBI, CGH: progenetix)

• Location: 1p36.3-p36.2
• Size: 17718  bp
• exons: 11
• DNA sequence (Human): NC_000001

• CGH (1p36.2):  Losses (%) -6.3   Gain (%)  0.0   Amplifications  0.0

• Mutations and SNPs (According to HGMD and SNP)

• HGMD :
• SNPs: 2023

• m-RNA                       (According to NCBI and CGAP)

• mRNA sequence (Human): NM_001428

• Size: 1812 bp

• cDNA libraries: eno1

• Protein                        (According to SwissProt, Swiss2D, PDB, UniProt)

• Size: 434 amino acids;  47169 Da

• Catalytic activity: phosphopyruvate hydtratase activity. 2 Phospho D Glycerate = Phosphoenolpyruvate + H2o.

                                      The Chemical Reactions and Pathways Resulting in the Breakdown of a Monosaccharide

                                      (generally Glucose) Into Pyruvate with the Concomitant Production of a Small Amount of Atp.          

                                      Pyruvate May Be Converted to Ethanol Lactate or Other Small Molecules or Fed Into the Tca Cycle. 

                                      Chain B

• COFACTOR: Magnesium. Required for catalysis and for stabilizing the dimer

• Subcellular location: Cytoplasm. Cell membrane. Cytoplasm, myofibril, sarcomere, M-band. Note=Can translocate to the plasma membrane in either the homodimeric (alpha/alpha) or heterodimeric (alpha/gamma) form. ENO1 is localized to the M-band.

          Isoform MBP-1: Nucleus.

• Protein domains

• Protein sequence (Human): P06733

• Homologous genes: 68183

• 2D PAGE: P06733

• 3D Structure: 2al2

• PTM: ENO1B

• Pathways and interactions (According to BioCarta, DIP)

• Pathway: GLYCOLYSIS/GLUCONEOGENESIS BIOCARTA, KEGG

• Protein interactions: eno1

• Tissue

  (According to GeneNote, PubMed, HPA)

• Tissue expression: PubMed Reference
• Human Protein Atlas (HPA): ENO1

• Clinical                            (According to OMIM, PubMed)

• OMIM : 172430
• PubMed:    Early detection      Diagnosis         Prognosis        Therapy