EPHB4

                                                                                              (Ephrin type-B receptor 4 precursor)

  • Alias                                 (According to NCBI)

 
  • EphB4
  • HTK
  • MYK1
  • TYRO11
  • Tyro11
  • ephrin receptor EphB4 
  • hepatoma transmembrane kinase
  • Ephrin type-B receptor 4 precursor (EC 2.7.1.112) (Tyrosine-protein kinase receptor HTK)

  • Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The protein encoded by this gene binds to ephrin-B2 and plays an essential role in vascular development.
  • Location: 7q22
  • Orientation: Minus strand
  • Size:24,840 bases
  • 17 Exons
  • DNA Sequence: NT_007933

 

                  

  • CGH (7q22):  Losses (%)  -2.8 Gain (%)  12.3 

  • Mutations and SNPs (According to HGMD and SNP)
  • m-RNA                       (According to NCBI and CGAP)

 
  • Size: 987 amino acids; 108269 Da
  • Sub cellular location: Type I membrane protein
  • Catalytic activity: ATP + a protein tyrosine = ADP + protein tyrosine phosphate
  • Protein domains:

               

                                

  • Protein sequence: P54760
  • Homologous genes: EPHB4
  • 2D PAGE:
  • 3D Structure:
  • PTM:
  • Pathways and interactions (According to BioCarta, DIP)
  • Pathways:
  • Interactions:
  • Clinical                            (According to OMIM, PubMed)