EPHX1

                                                                        (Epoxide hydroxylase 1, microsomal (xenobiotic))

  • Alias                                 (According to NCBI)

 
  • EPHX
  • EPOX
  • MEH
  • Epoxide hydroxylase 1, microsomal (xenobiotic)
  • epoxide hydrolase 1, microsomal (xenobiotic) 
  • Epoxide hydrolase 1 (EC 3.3.2.3) (Microsomal epoxide hydrolase) (Epoxide hydratase).

  • Epoxide hydrolase plays an important role in both the activation and detoxification of exogenous chemicals such as polycyclic aromatic hydrocarbons. It is a biotransformation enzyme that catalyzes the hydrolysis of arene and aliphatic epoxides to less reactive and more water soluble dihydrodiols by the trans addition of water.
  • Location:1q42.1
  • Orientation: Plus strand
  • Size:35,409 bases
  • 9 Exons
  • DNA Sequence: NT_004559

            

  • CGH (1q42.1):  Losses (%)  -0.6 Gain (%)  11.7 

  • Mutations and SNPs (According to HGMD and SNP)
  • m-RNA                       (According to NCBI and CGAP)

 
  • Size: 455 amino acids; 52949 Da
  • Sub cellular location: Membrane-bound on microsomes
  • Catalytic activity: An epoxide + H(2)O = a glycol
  • Protein domains:

                   

                              
  • Pathways and interactions (According to BioCarta, DIP)
  • Clinical                            (According to OMIM, PubMed)