EPLIN

                                                                                      (epithelial protein lost in neoplasm beta)

  • Alias                                 (According to NCBI)

 
  • EPLIN
  • SREBP3
  • LIMA1

  • EPLIN is a cytoskeleton-associated protein that inhibits actin filament depolymerization and cross-links filaments in bundles. Preferentially expressed in human epithelial cells. Two EPLIN isoforms, a 600 amino acid EPLIN-alpha and a 759 amino acid EPLIN-beta, are detected in primary epithelial cells of oral mucosa, prostate and mammary glands. The expression of EPLIN-alpha is either down-regulated or lost in the majority of cancer cell lines. The amino acid sequence of EPLIN is characterized by the presence of a single centrally located LIM domain. Both EPLIN isoforms suppress cell proliferation when overexpressed.
  • Location: 12q13
  • 11 Exons
  • DNA Sequence: NT_029419

  • CGH (12q13):  Losses (%)  -1.7 Gain (%)  8.4 
  • Mutations and SNPs (According to HGMD and SNP)
  • m-RNA                       (According to NCBI and CGAP)

 
  • Size: 759 amino acids; 85225 Da
  • Sub cellular location: Cytoplasmic. This cytoskeletal protein co- localizes with actin stress fibers and focal adhesion plaques.
  • Protein domains:

                 

                                           
  • Pathways and interactions (According to BioCarta, DIP)
  • Clinical                            (According to OMIM, PubMed)