Alias (According to NCBI)
- CDHF7
- ME5
- FAT tumor suppressor (Drosophila) homolog
- FAT tumor suppressor homolog 1 (Drosophila)
- cadherin ME5
- cadherin family member 7 precursor
- cadherin-related tumor suppressor homolog precursor
- homolog of Drosophila Fat protein
- homolog of Drosophila Fat protein precursor
- homolog of Drosophila tumor suppressor Fat precursor
- Cadherin-related tumor suppressor homolog precursor (Fat protein homolog).
Description
(According to SwissProt)
- This gene is an ortholog of the Drosophila fat gene, which encodes a tumor suppressor essential for controlling cell proliferation during Drosophila development. The gene product is a member of the cadherin superfamily, a group of integral membrane proteins characterized by the presence of cadherin-type repeats. In addition to containing 34 tandem cadherin-type repeats, the gene product has five epidermal growth factor (EGF)-like repeats and one laminin A-G domain. This gene is expressed at high levels in a number of fetal epithelia. Its product probably functions as an adhesion molecule and/or signaling receptor, and is likely to be important in developmental processes and cell communication. Transcript variants derived from alternative splicing and/or alternative promoter usage exist, but they have not been fully described.
- Chromosomal location
(According to NCBI, CGH: progenetix)
- Location: 4q34-q35
- Orientation: minus strand
- Size: 136039 bp
- 24 exons
- DNA sequence (Human): NC_000004
CGH (4q34-35): Losses (%) -19.6 Gain (%) 0.6
- HGMD :
- SNPs: FAT
- Size:4590 amino acids; 506273 Da
- Catalytic activity:
Subcellular location: Type I membrane protein (By similarity).
Protein domains
Pathway:
Protein interactions:
- Tissue expression: PubMed Reference
- Human Protein Atlas (HPA):
OMIM: 600976
PubMed: Early detection Diagnosis Prognosis Therapy