FGG

(fibrinogen, gamma polypeptide )

 

  • Alias                                 (According to NCBI)

 
  • FIBRINOGEN GAMMA-A CHAIN PRECURSOR 
  • fibrinogen, gamma polypeptide 
  • Fibrinogen gamma chain precursor (PRO2061).

  • The protein encoded by this gene is the gamma component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in this gene lead to several disorders, including dysfibrinogenemia, hypofibrinogenemia and thrombophilia. Alternative splicing results in two isoforms, varying in the carboxy-terminus.
  • Location: 4q28
  • Orientation: minus strand
  • Size: 8515 bp
  • 10  exons
  • DNA sequence (Human): NC_000004

  • CGH (4q28):  Losses (%)  -20.1  Gain (%)  0.6  

  • Mutations and SNPs (According to HGMD and SNP)

 
  • m-RNA                       (According to NCBI and CGAP)

 
  • Size: 453 amino acids; 51511 Da
  • Catalytic activity:

  • Subcellular location:

  • Protein domains

  • Pathways and interactions (According to BioCarta, DIP)

  • Pathway:

  1. Acute Myocardial Infarction

  2. Extrinsic Prothrombin Activation Pathway

  3. Fibrinolysis Pathway

  4. Intrinsic Prothrombin Activation Pathway

  • Protein interactions:

 

  • Clinical                            (According to OMIM, PubMed)