FYB

(FYN Binding Protein)

 

  • Alias                                 (According to NCBI)

 
  • ADAP
  • PRO0823
  • SLAP-130
  • FYN binding protein (FYB-120/130)
  • FYN-binding protein (FYB-120/130)
  • FYN-binding protein (FYN-T-binding protein) (FYB-120/130) (p120/p130) (SLP-76 associated
    phosphoprotein) (SLAP-130).
  • This gene codes for a protein that acts as an adapter protein of the FYN and SH2-domain-containing leucocyte protein-76 (SLP76) signaling cascades in T cells. Modulates the expression of interleukin-2 (IL-2).
  • Location: 5p13.1
  • Orientation: minus strand
  • Size: 114310 bp
  • 21 exons
  • DNA sequence (Human):NC_000005.

  • CGH (5p13.1):  Losses (%) -5.6    Gain (%)  12.8  

  • Mutations and SNPs (According to HGMD and SNP)
  • HGMD:
  • SNPs: FYB
  • m-RNA                       (According to NCBI and CGAP)

 
  • Size: 783 amino acids; 85421 Da
  • Catalytic activity:

  • Subcellular location: Nuclear and cytoplasmic (By similarity)

  • Protein domains

 

                                   

  • Protein sequence (Human): O15117

  • Homologous genes: FYB

  • 2D PAGE:O15117

  • 3D Structure:

  • PTM: FYB
  • Pathways and interactions (According to BioCarta, DIP)

  • Pathway:

  • Protein interactions:
  • Clinical                            (According to OMIM, PubMed)