GPX3

 Glutathione peroxidase 3 (plasma)

 

  • Alias                                 (According to NCBI)

 
  • glutathione peroxidase 3 (plasma)
  • Plasma glutathione peroxidase precursor (EC 1.11.1.9) (GSHPx-P) (Extracellular glutathione
    peroxidase) (GPx-P).

  • Glutathione peroxidase catalyzes the reduction of hydrogen peroxide, organic hydroperoxide, and lipid peroxides by reduced glutathione and functions in the protection of cells against oxidative damage. Human plasma glutathione peroxidase has been shown to be a selenium-containing enzyme. GPX3 expression appears to be tissue-specific.
  • Location: 5q23
  • Orientation: plus strand
  • Size: 8,630  bp
  •   5 exons
  • DNA sequence (Human):   NC_000005

  • CGH (5q23):  Losses (%) -22.3  Gain (%)  1.7 

  • Mutations and SNPs (According to HGMD and SNP)

 
  • m-RNA                       (According to NCBI and CGAP)

 

  • mRNA sequence (Human): NM_002084

  • Size: 1856 bp

  • cDNA libraries:GPX3
  • Size: 226 amino acids; 25505 Da
  • Catalytic activity: 2 glutathione + H(2)O(2) = glutathione disulfide + 2 H(2)O.

  • Subcellular location: Secreted.

  • Protein domains

 
  • Pathways and interactions (According to BioCarta, DIP)

  • Protein interactions:

 

  • Clinical                            (According to OMIM, PubMed)