GSK3B

                                                                                             (Glycogen synthase kinase-3 beta)

  • Alias                                 (According to NCBI)

 
  • glycogen synthase kinase 3 beta
  • Glycogen synthase kinase-3 beta (EC 2.7.1.37) (GSK-3 beta)

  • Glycogen synthase kinase-3 (GSK3) is a proline-directed serine-threonine kinase that was initially identified as a phosphorylating and inactivating glycogen synthase. Two isoforms, alpha  and beta, show a high degree of amino acid homology. GSK3B is involved in energy metabolism, neuronal cell development, and body pattern formation
  • Location:3q13.3
  • Orientation: Minus strand
  • Size: 267,742 bases
  • 12 Exons
  • DNA Sequence: NT_005612

            

  • CGH (3q13.3):  Losses (%)  -3.4 Gain (%)  16.2 

  • Mutations and SNPs (According to HGMD and SNP)
  • m-RNA                       (According to NCBI and CGAP)

 
  • Size:420 amino acids; 46744 Da
  • Catalytic activity: ATP + a protein = ADP + a phosphoprotein
  • Protein domains:

            

                               
  • Pathways and interactions (According to BioCarta, DIP)
  • Clinical                            (According to OMIM, PubMed)