Alias (According to NCBI)
- GST5
- GSTB
- GSTM3-3
- GTM3
- MGC3310
- MGC3704
- GST class-mu 3
- S-(hydroxyalkyl)glutathione lyase M3
- brain GST
- glutathione S-alkyltransferase M3
- glutathione S-aralkyltransferase M3
- glutathione S-aryltransferase M3
- glutathione S-transferase M3 (brain)
- glutathione S-transferase, Mu-3
- Glutathione S-transferase Mu 3 (EC 2.5.1.18) (GSTM3-3) (GST class-mu 3) (hGSTM3-3)
Description
(According to SwissProt)
Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. Mutations of this class mu gene have been linked with a slight increase in a number of cancers, likely due to exposure with environmental toxins.
- Chromosomal location
(According to NCBI, CGH: progenetix)
- Location:1p13.3
- Orientation: Minus strand
- Size: 7,106 bases
- 9 Exons
- DNA Sequence: NT_019273
CGH (1p13.3): Losses (%) -8.4 Gain (%) 2.2
- Size: 224 amino acids; 26428 Da
- Sub cellular location: Cytoplasmic
- Catalytic activity: RX + glutathione = HX + R-S-glutathione
- Protein domains:
- Pathways:
- Interactions:
- Tissue expression: PubMed Reference
- Human Protein Atlas (HPA): CAB017130
- OMIM:138390
- PubMed: Early detection Diagnosis Prognosis Therapy