GSTP1

Glutathione S-transferase pi

 

  • Alias                                 (According to NCBI)

 
  • DFN7
  • FAEES3
  • GST3
  • PI
  • fatty acid ethyl ester synthase III
  • glutathione S-transferase pi
  • Glutathione S-transferase P (EC 2.5.1.18) (GST class-pi) (GSTP1-1).

  • Glutathione S-transferases (GSTs) are a family of enzymes that play an important role in detoxification by catalyzing the conjugation of many hydrophobic and electrophilic compounds with reduced glutathione. Based on their biochemical, immunologic, and structural properties, the soluble GSTs are categorized into 4 main classes: alpha, mu, pi, and theta. The glutathione S-transferase pi gene (GSTP1) is a polymorphic gene encoding active, functionally different GSTP1 variant proteins that are thought to function in xenobiotic metabolism and play a role in susceptibility to cancer, and other diseases.
  • Location: 11q13
  • Orientation: plus strand
  • Size: 2838  bp
  • 7 exons
  • DNA sequence (Human): NC_000011

  • CGH (11q13) :  Losses (%)  3.4  Gain (%)  34.1  
  • Mutations and SNPs (According to HGMD and SNP)

 
  • m-RNA                       (According to NCBI and CGAP)

 
  • Size: 209 amino acids; 23225 Da
  • Catalytic activity: RX + glutathione = HX + R-S-glutathione.

  • Subcellular location:

  • Protein domains

  • Pathways and interactions (According to BioCarta, DIP)

 

 
  • Clinical                            (According to OMIM, PubMed)