GSTT1

                                                                                    (Glutathione S-transferase theta 1)

  • Alias                                 (According to NCBI)

 
  • glutathione S-transferase theta 1 
  • Glutathione S-transferase theta 1 (EC 2.5.1.18) (GST class-theta) (Glutathione transferase T1-1).

  • Glutathione S-transferase (GSTs) theta 1 (GSTT1) is a member of a superfamily of proteins that catalyze the conjugation of reduced glutathione to a variety of electrophilic and hydrophobic compounds. Human GSTs can be divided into five main classes: Alpha, Mu, Pi, Theta, and Zeta. The theta class includes GSTT1 and GSTT2. The GSTT1 and GSTT2 share 55% amino acid sequence identity and both of them were claimed to have an important role in human carcinogenesis. GSTT1 gene is located approximately 50kb away from the GSTT2 gene.
  • Location: 22q11.23
  • Orientation: Minus strand
  • Size: 8,130 bases
  • 5 Exons
  • DNA Sequence: NT_011520

             

  • CGH (22q11.23):  Losses (%)  -1.1 Gain (%)  15.1 
  • Mutations and SNPs (According to HGMD and SNP)
  • m-RNA                       (According to NCBI and CGAP)

 
  • Size:239 amino acids; 27204 Da
  • Sub cellular location: Cytoplasmic
  • Protein domains:

         

                                        

  • Protein sequence: P30711
  • Homologous genes: GST-T1
  • 2D PAGE:
  • 3D Structure:
  • PTM: GSTT1
  • Pathways and interactions (According to BioCarta, DIP)
  • Clinical                            (According to OMIM, PubMed)