HCAM

CD44 cell adhesion molecule

 

  • Alias                                 (According to NCBI)

 
  • CD44R
  • CDW44
  • ECMR-III
  • IN
  • INLU
  • LHR
  • MC56
  • MDU2
  • MDU3
  • MGC10468
  • MIC4
  • MUTCH-I
  • Pgp1
  • CD44 antigen (homing function and Indian blood group system)
  • CDW44 antigen
  • GP90 lymphocyte homing/adhesion receptor
  • Hermes antigen
  • Lutheran inhibitor, dominant
  • antigen gp90 homing receptor
  • cell adhesion molecule (CD44)
  • cell surface glycoprotein CD44
  • extracellular matrix receptor-III
  • heparan sulfate proteoglycan
  • hyaluronate receptor
  • monoclonal antibody A3D8
  • phagocytic glycoprotein I
  • CD44 antigen precursor (Phagocytic glycoprotein I) (PGP-1) (HUTCH-I) (Extracellular matrix
    receptor-III) (ECMR-III) (GP90 lymphocyte homing/adhesion receptor) (Hermes antigen) (Hyaluronate
    receptor) (Heparan sulfate proteoglycan) (Epican) (CDw44).

  • The protein encoded by this gene is a cell-surface glycoprotein involved in cell-cell interactions, cell adhesion and migration. It is a receptor for hyaluronic acid (HA) and can also interact with other ligands, such as osteopontin, collagens, and matrix metalloproteinases (MMPs). This protein participates in a wide variety of cellular functions including lymphocyte activation, recirculation and homing, hematopoiesis, and tumor metastasis. Transcripts for this gene undergo complex alternative splicing that results in many functionally distinct isoforms, however, the full length nature of some of these variants has not been determined. Alternative splicing is the basis for the structural and functional diversity of this protein, and may be related to tumor metastasis.
  • Location: 11p13
  • Orientation: plus strand
  • Size: 90845 bp
  • 18 exons
  • DNA sequence (Human): NC_000011

  • CGH (11p13):  Losses (%)  -14.5  Gain (%)  4.5  
  • Mutations and SNPs (According to HGMD and SNP)
  • m-RNA                       (According to NCBI and CGAP)

 
  • Size: 742 amino acids; 81553 Da
  • Catalytic activity:

  • Subcellular location: Type I membrane protein.

  • Protein domains

 
  • Pathways and interactions (According to BioCarta, DIP)

  • Pathway:

  1. Adhesion Molecules on Lymphocyte

  2. Monocyte and its Surface Molecules

  3. Neutrophil and Its Surface Molecules

  • Protein interactions: DIP: 1121N
  • Clinical                            (According to OMIM, PubMed)