HIF1A

                                                                                       (hypoxia-inducible factor 1, alpha subunit)

  • Alias                                 (According to NCBI)

 
  • HIF-1ALPHA
  • HIF-1alpha 
  • HIF1-ALPHA 
  • MOP1
  • ARNT interacting protein
  • hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
  • member of PAS superfamily 1
  • Hypoxia-inducible factor 1 alpha (HIF-1 alpha) (HIF1 alpha) (ARNT interacting protein) (Member of PAS protein 1) (MOP1).

  • Hypoxia-inducible factor-1 (HIF1) is a transcription factor found in mammalian cells cultured under reduced oxygen tension that plays an essential role in cellular and systemic homeostatic responses to hypoxia. HIF1 is a heterodimer composed of an alpha subunit and a beta subunit. The beta subunit has been identified as the aryl hydrocarbon receptor nuclear translocator (ARNT). This gene encodes the alpha subunit of HIF-1. Overexpression of a natural antisense transcript (aHIF) of this gene has been shown to be associated with nonpapillary renal carcinomas.
  • Location:14q21-q24
  • Orientation: Plus strand
  • Size: 52,737 bases
  • 15 Exons
  • DNA Sequence: NT_026437

           

  • CGH (14q21-24):  Losses (%)  -3.4 Gain (%)  6.7 

  • Mutations and SNPs (According to HGMD and SNP)
  • m-RNA                       (According to NCBI and CGAP)

 
  • Size: 826 amino acids; 92670 Da
  • Sub cellular location: Cytoplasmic in normoxia, nuclear translocation in response to hypoxia
  • Protein domains:

                                              

  • Pathways and interactions (According to BioCarta, DIP)
  • Clinical                            (According to OMIM, PubMed)