HSPA1A

                                                                                           (Heat shock 70kDa protein 1A)

  • Alias                                 (According to NCBI)

 
  • HSP70-1 
  • HSP72
  • HSPA1 
  • dnaK-type molecular chaperone HSP70-1 
  • heat shock 70kD protein 1
  • heat shock 70kD protein 1A 
  • heat shock 70kDa protein 1A
  • heat shock-induced protein
  • Heat shock 70 kDa protein 1 (HSP70.1) (HSP70-1/HSP70-2)

  • This intronless gene encodes a 70kDa heat shock protein which is a member of the heat shock protein 70 family. In conjuction with other heat shock proteins, this protein stabilizes existing proteins against aggregation and mediates the folding of newly translated proteins in the cytosol and in organelles. It is also involved in the ubiquitin-proteasome pathway through interaction with the AU-rich element RNA-binding protein 1. The gene is located in the major histocompatibility complex class III region, in a cluster with two closely related genes which encode similar proteins.
  • Location:6p21.3
  • Orientation: Plus strand
  • Size: 2,382 bases
  • 1 Exon
  • DNA Sequence: NT_007592

 

  • CGH (6p21.3):  Losses (%)  -1.1  Gain (%)  7.3 

  • Mutations and SNPs (According to HGMD and SNP)
  • m-RNA                       (According to NCBI and CGAP)

 
  • Size: 641 amino acids; 70052 Da
  • Protein domains:

                  

  • Pathways and interactions (According to BioCarta, DIP)
  • Clinical                            (According to OMIM, PubMed)