HSPB1

                                                                                     (Heat shock 27kDa protein 1)

Alias                                 (According to NCBI)	HS.76067 HSP27  HSP28  Hsp25  heat shock 27kD protein 1  heat shock 27kDa protein 1  Heat-shock protein beta-1 (HspB1) (Heat shock 27 kDa protein) (HSP 27) (Stress-responsive protein 27) (SRP27) (Estrogen-regulated 24 kDa protein) (28 kDa heat shock protein)
Description    (According to SwissProt)	Cytoplasmic in interphase cells. Co localizes with mitotic spindles in mitotic cells. Translocates to the nucleus during heat shock.
Chromosomal location (According to NCBI, CGH: progenetix)	Location:7q11.23 Orientation: Plus strand Size: 1,690 bases 3 Exons DNA Sequence: NT_007933                         CGH (7q11.23):  Losses (%)  -2.8  Gain (%)  9.5
Mutations and SNPs (According to HGMD and SNP)	HGMD: SNPs: HSPB1
m-RNA                       (According to NCBI and CGAP)	m-RNA Sequence: NM_001540 Size: 865 bp c-DNA Libraries: HSPB1
Protein                        (According to SwissProt, Swiss2D, PDB, dbPTM)	Size: 205 amino acids; 22782 Da Sub cellular location: Cytoplasmic in interphase cells. Co localizes with mitotic spindles in mitotic cells. Translocates to the nucleus during heat shock. Protein domains:        Protein sequence: P04792 Homologous genes: HSPB1 2D PAGE: 3D Struccture: PTM: HSPB1
Pathways and interactions (According to BioCarta, DIP)	Pathways: Downregulated of MTA-3 in ER-negative Breast Tumors p38 MAPK Signaling Pathway Stress Induction of HSP Regulation Interactions: P04792.
Tissue (According to GeneNote, PubMed, HPA)	Tissue expression: PubMed Reference Human Protein Atlas (HPA): CAB002061
Clinical                            (According to OMIM, PubMed)	OMIM:602195 PubMed: Early detection      Diagnosis         Prognosis        Therapy