ID2

                                                                               (DNA-binding protein inhibitor ID2)

  • Alias                                 (According to NCBI)

 
  • ID2A
  • ID2H 
  • MGC26389
  • DNA-binding protein inhibitor ID2
  • helix-loop-helix protein ID2
  • inhibitor of DNA binding 2, dominant negative helix-loop-helix protein 
  • inhibitor of differentiation 2
  • DNA-binding protein inhibitor ID-2

  • The protein encoded by this gene belongs to the inhibitor of DNA binding (ID) family, members of which are transcriptional regulators that contain a helix-loop-helix (HLH) domain but not a basic domain. Members of the ID family inhibit the functions of basic helix-loop-helix transcription factors in a dominant-negative manner by suppressing their heterodimerization partners through the HLH domains. This protein may play a role in negatively regulating cell differentiation.
  • Location:2p25
  • Orientation: Plus strand
  • Size: 2,397 bases
  • 3 Exons
  • DNA Sequence: NT_005334

  • CGH (2p25):  Losses (%)  -11.2 Gain (%)  4.5 

  • Mutations and SNPs (According to HGMD and SNP)
  • HGMD:
  • SNPs: ID2
  • m-RNA                       (According to NCBI and CGAP)

 
  • Size:134 amino acids; 14917 Da
  • Sub cellular location: Nuclear
  • Protein domains:

              

  • Protein sequence: Q02363
  • Homologous genes: ID2
  • 2D PAGE:
  • 3D Structure:
  • PTM: ID2
  • Pathways and interactions (According to BioCarta, DIP)
  • Clinical                            (According to OMIM, PubMed)