ID4

 Inhibitor of DNA Binding 4

 

  • Alias                                 (According to NCBI)

 
  • Inhibitor of DNA binding 4, dominant negative helix-loop-helix
  • inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
  • DNA-binding protein inhibitor ID-4.

  • Transcription factors containing a basic helix-loop-helix (bHLH) motif regulate expression of tissue-specific genes in a number of mammalian and insect systems. DNA-binding activity of the bHLH proteins is dependent on formation of homo- and/or heterodimers. Dominant-negative HLH proteins encoded by Id-related genes, such as ID4, also contain the HLH-dimerization domain but lack the DNA-binding basic domain. Consequently, Id proteins inhibit binding to DNA and transcriptional transactivation by heterodimerization with bHLH proteins (Pagliuca et al., 1995).
  • Location: 6p22-p21
  • Orientation: plus strand
  • Size: 3,298 bp
  • 3 exons
  • DNA sequence (Human): NC_000006

 

 


 

  • CGH (6p22-21):  Losses (%) -1.7  Gain (%) 6.7  
  • Mutations and SNPs (According to HGMD and SNP)

 
  • m-RNA                       (According to NCBI and CGAP)

 

  • mRNA sequence (Human):  NM_001546

  • Size: 2389  bp

  • cDNA libraries: ID4
  • Size: 161 amino acids; 16622 Da
  • Catalytic activity:

  • Subcellular location: Nuclear.

  • Protein domains

 

 

 

  • Protein sequence (Human): P47928

  • Homologous genes: ID4

  • 2D PAGE: P47928

  • 3D Structure:

  • PTM: ID4
  • Pathways and interactions (According to BioCarta, DIP)

  • Pathway: 

  • Protein interactions:

 

  • Clinical                            (According to OMIM, PubMed)