IK

IK cytokine, down-regulator of HLAII

  • Alias                                 (According to NCBI)

 
  • CSA2 
  • RED 
  • IK cytokine, down-regulator of HLA II
  • IK factor
  • RD element 
  • chondrosarcoma-associated protein 2 
  • prer protein
  • Red protein (RER protein) (IK factor) (Cytokine IK).

  • The protein encoded by this gene was identified by its RED repeat, a stretch of repeated arginine, glutamic acid and aspartic acid residues. The protein localizes to discrete dots within the nucleus, excluding the nucleolus. Its function is unknown. This gene maps to chromosome 5; however, a pseudogene may exist on chromosome 2.
  • Location: 5q31.3
  • Orientation: plus strand
  • Size: 14531 bp
  • 20 exons
  • DNA sequence (Human): NC_000005

  • CGH (5q31.3):  Losses (%)  -10.6  Gain (%)  3.4 

  • Mutations and SNPs (According to HGMD and SNP)
  • HGMD:
  • SNPs: IK

 
  • m-RNA                       (According to NCBI and CGAP)

 

  • mRNA sequence (Human): NM_006083

  • Size: 1785 bp

  • cDNA libraries: IK
  • Size: 557 amino acids; 65630 Da
  • Catalytic activity:

  • Subcellular location: Nuclear.

  • Protein domains

  • Protein sequence (Human): Q13123

  • Homologous genes: IK

  • 2D PAGE: Q13123

  • 3D Structure:

  • PTM:
  • Pathways and interactions (According to BioCarta, DIP)

  • Pathway:

  • Protein interactions:

  • Clinical                            (According to OMIM, PubMed)