IL4R

(Interleukin 4 receptor)

 

  • Alias                                 (According to NCBI)

 
  • CD124
  • IL4RA
  • interleukin 4 receptor
  • Interleukin-4 receptor alpha chain precursor (IL-4R-alpha) (CD124 antigen) [Contains: Soluble
    interleukin-4 receptor alpha chain (sIL4Ralpha/prot) (IL-4-binding protein) (IL4-BP)].
  • This gene encodes the alpha chain of the interleukin-4 receptor, a type I transmembrane protein that can bind interleukin 4 and interleukin 13 to regulate IgE production. The encoded protein also can bind interleukin 4 to promote differentiation of Th2 cells. A soluble form of the encoded protein can be produced by an alternate splice variant or by proteolysis of the membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. Allelic variations in this gene have been associated with atopy, a condition that can manifest itself as allergic rhinitis, sinusitus, asthma, or eczema. Two transcript variants encoding different isoforms, a membrane-bound and a soluble form, have been found for this gene.
  • Location: 16p11.2-12.1
  • Orientation: plus   strand
  • Size: 34709 bp
  •  11 exons
  • DNA sequence (Human):NC_000016  

  • CGH (16p11.2-12.1):  Losses (%)   -1.1      Gain (%)  5.0    
  • Mutations and SNPs (According to HGMD and SNP)
  • m-RNA                       (According to NCBI and CGAP)

 
  • Size:825 amino acids; 89658 Da
  • Catalytic activity:

  • Subcellular location: Type I membrane protein. Isoform 2 is secreted.

  • Protein domains

 

                               
  • Pathways and interactions (According to BioCarta, DIP)

 

 
  • Clinical                            (According to OMIM, PubMed)