Alias (According to NCBI)
- CDw128b
- CMKAR2
- CXCR2
- IL8R2
- IL8RA
- CXCR2 gene for IL8 receptor type B
- GRO/MGSA receptor
- chemokine (CXC) receptor 2
- high affinity interleukin-8 receptor B
- interleukin 8 receptor B
- interleukin 8 receptor type 2
- interleukin 8 receptor, beta
- High affinity interleukin-8 receptor B (IL-8R B) (CXCR-2) (GRO/MGSA
receptor) (IL-8 receptor type
2) (CDw128b).
Description
(According to SwissProt)
- The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. This receptor also binds to chemokine (C-X-C motif) ligand 1 (CXCL1/MGSA), a protein with melanoma growth stimulating activity, and has been shown to be a major component required for serum-dependent melanoma cell growth. This receptor mediates neutrophil migration to sites of inflammation. The angiogenic effects of IL8 in intestinal microvascular endothelial cells are found to be mediated by this receptor. Knockout studies in mice suggested that this receptor controls the positioning of oligodendrocyte precursors in developing spinal cord by arresting their migration. This gene, IL8RA, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36.
- Chromosomal location
(According to NCBI, CGH: progenetix)
- Location: 2q35
- Orientation: plus strand
- Size: 11230 bp
- 3 exons
- DNA sequence (Human): NC_000002
CGH (2q35): Losses (%) -6.7 Gain (%) 4.5
- HGMD:
- SNPs: IL8RB
- Size: 360 amino acids; 40759 Da
- Catalytic activity:
Subcellular location : integral membrane protein.
Protein domains
Pathway:
Protein interactions: 3782N
- Tissue expression: PubMed Reference
- Human Protein Atlas (HPA): CAB016268
OMIM: 146928
PubMed: Early detection Diagnosis Prognosis Therapy