ING1

                                                                             (Inhibitor of growth family, member 1)

  • Alias                                 (According to NCBI)

 
  • p33ING1
  • Homo sapiens growth inhibitor p33ING1 (ING1) mRNA, complete cds
  • growth inhibitor ING1
  • inhibitor of growth 1 
  • inhibitor of growth family, member 1
  • tumor suppressor ING1
  • Inhibitor of growth protein 1

  • This gene encodes a tumor suppressor protein that can induce cell growth arrest and apoptosis. The encoded protein is a nuclear protein that physically interacts with the tumor suppressor protein TP53 and is a component of the p53 signaling pathway. Reduced expression and rearrangement of this gene have been detected in various cancers.
  • Location: 13q34
  • Orientation: Plus strand
  • Size: 8,338 bases
  • 2 Exons
  • DNA Sequence: NT_009952

  • CGH (13q34):  Losses (%) -6.1  Gain (%)  6.1  
  • Mutations and SNPs (According to HGMD and SNP)
  • m-RNA                       (According to NCBI and CGAP)

 
  • Size: 422 amino acids; 46780 Da
  • Sub cellular location: Nuclear
  • Protein domains:

               

                                            

  • Protein sequence: Q9UK53
  • Homologous genes: ING1
  • 2D PAGE:
  • 3D Structure:
  • PTM: ING1
  • Pathways and interactions (According to BioCarta, DIP)
  • Clinical                            (According to OMIM, PubMed)