KRT10

(Keratin 10)

 

  • Alias                                 (According to NCBI)

 
  • K10 
  • KPP 
  • KERATIN, TYPE I CYTOSKELETAL 10
  • cytokeratin 10 
  • keratin 10 (epidermolytic hyperkeratosis; keratosis palmaris et plantaris) 
  • Keratin, type I cytoskeletal 10 (Cytokeratin 10) (K10) (CK 10).
  • This gene encodes a member of the type I (acidic) cytokeratin family, which belongs to the superfamily of intermediate filament (IF) proteins. Keratins are heteropolymeric structural proteins which form the intermediate filament. These filaments, along with actin microfilaments and microtubules, compose the cytoskeleton of epithelial cells. Mutations in this gene are associated with epidermolytic hyperkeratosis. This gene is located within a cluster of keratin family members on chromosome 17q21
  • Location:17q21.2
  • Orientation:minus strand
  • Size: 4478 bp
  • 10  exons
  • DNA sequence (Human): NC_000017

  • CGH (17q21.2):  Losses (%) -1.7  Gain (%)  7.8 

  • Mutations and SNPs (According to HGMD and SNP)
  • m-RNA                       (According to NCBI and CGAP)

 
  • Size : 593 amino acids; 59519 Da
  • Catalytic activity:

  • Subcellular location: intracellular,cytoplasm,cytoskeleton

  • Protein domains

 

                                    
  • Pathways and interactions (According to BioCarta, DIP)

  • Pathway:

  • Protein interactions:
 
  • Clinical                            (According to OMIM, PubMed)