KRT13

(Keratin 13)

 

  • Alias                                 (According to NCBI)

 
  • CK13 
  • MGC3781 
  • cytokeratin 13 
  • keratin, type I cytoskeletal 13 
  • Keratin, type I cytoskeletal 13 (Cytokeratin 13) (K13) (CK 13)

  • The protein encoded by this gene is a member of the keratin gene family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. Most of the type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. This type I cytokeratin is paired with keratin 4 and expressed in the suprabasal layers of non-cornified stratified epithelia. Mutations in this gene and keratin 4 have been associated with the autosomal dominant disorder White Sponge Nevus. The type I cytokeratins are clustered in a region of chromosome 17q21.2. Alternative splicing of this gene results in multiple transcript variants; however, not all variants have been described.
  • Location: 17q21.2
  • Orientation: minus strand
  • Size: 4632 bp
  • 7 exons
  • DNA sequence (Human):NC_000017.

 

  • CGH (17q21.2):  Losses (%) -1.7  Gain (%)  7.3 

  • Mutations and SNPs (According to HGMD and SNP)
  • m-RNA                       (According to NCBI and CGAP)

 
  • Size: 458 amino acids; 49586 Da
  • Catalytic activity:

  • Subcellular location: intracellular,cytoplasm,cytoskeleton,intermed filament

  • Protein domains

 

        

  • Pathways and interactions (According to BioCarta, DIP)

  • Pathway:

  • Protein interactions:
  • Clinical                            (According to OMIM, PubMed)