KRT 16

(Keratin 16)

 

 Alias
  • CK16 
  • K1CP 
  • KRT16A
  • NEPPK
  • cytokeratin 16
  • keratin 16 (focal non-epidermolytic palmoplantar keratoderma) 
  • keratin, type I cytoskeletal 16 
  • Keratin, type I cytoskeletal 16 (Cytokeratin 16) (K16) (CK 16).

 Description

 (According to SwissProt)
  • The protein encoded by this gene is a member of the keratin gene family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. Most of the type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains and are clustered in a region of chromosome 17q12-q21. This keratin has been coexpressed with keratin 14 in a number of epithelial tissues, including esophagus, tongue, and hair follicles. Mutations in this gene are associated with type 1 pachyonychia congenita, non-epidermolytic palmoplantar keratoderma and unilateral palmoplantar verrucous nevus.

 Chromosomal location

 (According to LocusLink,    Genatlas, CGAP, progenetix)
  • Location: 17q21.2
  • Orientation: minus strand
  • Size:   2987 bp
  • 8 exons
  • DNA sequence (Human):NC_000017. 

  • CGH (17q21.2):  Losses (%) -1.7  Gain (%)  7.8 

 Mutations & SNP 

 (According to HGMD, OrCGBD, SNP)

 mRNA

(According to CGED,

OrCGBD)

 Protein

 (According to SwissProt,   Pfam, Swiss2D, PDB, dbPTM)
  • Size: 472 amino acids; 51136 Da
  • Catalytic activity:

  • Subcellular location: intracellular,cytoplasm,cytoskeleton,intermed filament

  • Protein domains

 

 

Pathway & protein interactions

(According to BioCarta, DIP)

  • Pathway:

  • Protein interactions:

 Tissue

 (According to GeneNote - 

 expression array results)

  

 Clinical

 (According to Cancer Genetics, OMIM)