KRT3

(Keratin 3)

 

 Alias
  • CK3
  • Keratin-3 
  • 65 kDa cytokeratin 
  • cytokeratin 3 
  • keratin, type II cytoskeletal 3
  • Keratin, type II cytoskeletal 3 (Cytokeratin 3) (K3) (CK3) (65 kDa cytokeratin).

 Description

 (According to SwissProt)
  • The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the corneal epithelium with family member KRT12 and mutations in these genes have been associated with Meesmanns Corneal Dystrophy. The type II cytokeratins are clustered in a region of chromosome 12q12-q13.

 Chromosomal location

 (According to LocusLink,    Genatlas, CGAP, progenetix)
  • Location: 12q12-q13
  • Orientation: minus strand
  • Size: 6343 bp
  • 9 exons
  • DNA sequence (Human):  NC_000012.

  • CGH (12q12-13):  Losses (%) -1.7  Gain (%) 7.8    

 Mutations & SNP 

 (According to HGMD, OrCGBD, SNP)

 mRNA

(According to CGED, OrCGBD)

  • mRNA sequence (Human): NM_057088

  • Size: 2224 bp

  • cDNA libraries: KRT3

 Protein

 (According to SwissProt,   Pfam, Swiss2D, PDB, dbPTM)
  • Size: 629 amino acids; 64511 Da
  • Catalytic activity:

  • Subcellular location:

  • Protein domains

                               

Pathway & protein interactions

(According to BioCarta, DIP)

  • Pathway:

  • Protein interactions:

 Tissue

 (According to GeneNote - 

 expression array results)

 Clinical

 (According to Cancer Genetics, OMIM)