KRT4

Keratin 4

 

  • Alias                                 (According to NCBI)

 
  • CK4
  • CYK4
  • FLJ31692 
  • Keratin-4 
  • cytokeratin 4 
  • keratin, type II cytoskeletal 4
  • Keratin, type II cytoskeletal 4 (Cytokeratin 4) (K4) (CK4).

  • The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in differentiated layers of the mucosal and esophageal epithelia with family member KRT13. Mutations in these genes have been associated with White Sponge Nevus, characterized by oral, esophageal, and anal leukoplakia. The type II cytokeratins are clustered in a region of chromosome 12q12-q13.
  • Location: 12q12-q13
  • Orientation: minus strand
  • Size: 8,001 bp
  • 9  exons
  • DNA sequence (Human): NC_000012

  • CGH (12q12-13):  Losses (%) -1.7  Gain (%) 7.8
  • Mutations and SNPs (According to HGMD and SNP)
  • m-RNA                       (According to NCBI and CGAP)

 

  • mRNA sequence (Human):NM_002272

  • Size:  2617 bp

  • cDNA libraries:KRT4
  • Size: 534 amino acids; 57295 Da
  • Catalytic activity:

  • Subcellular location:

  • Protein domains


 
  • Pathways and interactions (According to BioCarta, DIP)

  • Pathway:

  • Protein interactions:

 

  • Clinical                            (According to OMIM, PubMed)