KRT8

(Keratin 8 )

 

 Alias
  • CARD2
  • CK8
  • CYK8
  • K2C8 
  • KO 
  • cardiac autoantigen 2, 120kD
  • cytokeratin 8
  • keratin, type II cytoskeletal 8
  • Keratin, type II cytoskeletal 8 (Cytokeratin 8) (K8) (CK 8).

 Description

 (According to SwissProt)
  • Receptor for EGF, but also for other members of the EGF family, as TGF-alpha, amphiregulin, betacellulin, heparin-binding EGF-like growth factor, GP30 and vaccinia virus growth factor. Is involved in the control of cell growth and differentiation.

 Chromosomal location

 (According to LocusLink,    Genatlas, CGAP, progenetix)
  • Location:12q13
  • Orientation: minus strand
  • Size: 7850 bp
  •  8 exons
  • DNA sequence (Human): NC_000012.

  • CGH (12q12-13):  Losses (%) -1.7  Gain (%) 7.8

 

 Mutations & SNP 

 (According to HGMD,OrCGBD, SNP)

 mRNA

(According to CGED,OrCGBD)

 Protein

 (According to SwissProt,   Pfam, Swiss2D, PDB, dbPTM)
  • Size:482 amino acids; 53543 Da
  • Catalytic activity:

  • Subcellular location: intracellular,cytoplasm,cytoskeleton,intermed filament

  • Protein domains

                                

Pathway & protein interactions

(According to BioCarta, DIP)

  • Pathway:

  • Protein interactions:

 Tissue

 (According to GeneNote - 

 expression array results)

 Clinical

 (According to Cancer Genetics, OMIM)